The Museum in Topoľčany was founded in 1961. The first permanent exhibition of the museum was opened in 1964 and its content was anthropology. Throughout its history, the museum has undergone remarkable developments and favorable changes that have resulted in the current appearance of the Tribeč Museum.

The museum mainly deals with documenting and collecting natural, archaeological, historical and ethnographic material. Since 1980, it has specialized in documenting hop growing, malting and brewing in Slovakia.

For visitors, the museum offers a remarkable and varied permanent exhibition called "Nature of the Central Ponitrie". Exposure through paleontological, geological, botanical and zoological collections exposes the living and inanimate nature of the region of Central Ponitrie.

Among the most valuable exhibits that the exposition abounds in, undoubtedly include the unique findings of the Tertiary octopus mastodonta - the upper part of the skeleton of the skull with a pair of crossed tusks and the lower jaw. Also interesting is the collection of products of the former glassworks in Uhrovec, the collection of historical weapons and the numismatic collection of Baron Stummer.