The Zemplín Museum in Michalovce was founded in 1957 as a Zemplín Museum of Homeland Studies, and since 1965, it has been operating under the present name. The museum's collection and expositions are located in the Baroque-Classicist manor house of the nobles of the municipalities of Staré and Michalovce. The manor house was built in the 17th century by the rebuilding of an older castle. The last time it was rebuilt in the 1930s when it got its present appearance.

Zemplín Museum documents the living and inanimate nature, the overall cultural - historical and economic development of the Zemplín region. Collections and expositions are located in the manor house. The manor house, the former administrative buildings as well as the reconstructed foundations of a significant sacral building - the rotunda, located in the museum area - are cultural monuments.